PARK YONG DOO

教授

PI,教授,問題性皮膚研究中心主任

教育背景

  • 1992.03 - 1996.02   Chonnam National University(韓,全南國立大學),本科生
  • 1996.09 - 1997.08   北京語言文化大學,進修生
  • 1997.09 - 2001.06   清華大學生物技術與工程系,研究生(碩博連讀)
  • 2001.07 - 2001.12   哈佛大學醫學院CBBSM中心,博士后

工作履歷

  • 2018.05 -       浙江清華長三角研究院問題性皮膚研究中心,主任
  • 2006.05 -       浙江清華長三角研究院生物技術與醫藥研究所,PI
  • 2004.09 - 2016.08   成均館大學醫學院(韓),研究教授
  • 2002.01 - 2007.03   三星集團生物醫藥研究中心,首席研究員
  • 2008.01 - 2011.01   南方醫科大學,特聘教授(兼職)

獎勵與榮譽(市級及以上)

  1. 國家高端外國專家
  2. 浙江省“西湖友誼獎”
  3. 嘉興市 “榮譽市民”
  4. 嘉興市高層次外國專家
  5. 寧波市重點高層次人才
  6. 嘉興市自然科學學術一等獎 (2012年)

承擔重要項目

  1. 韓國2001健康研究與開發項目,韓國保健福祉部(01-PJ3-PG6-01GN12-0001)
  2. 韓國21世紀健康研究與開發項目,韓國保健福祉部(03-PJ10-PG6-GN01-002)
  3. 國家高端外國專家項目
  4. 創新嘉興精英引領計劃高層次外國專家項目

代表性著作及論文

Atopic dermatitis research (特應性皮炎研究):

  1. Yin SJ, Cho IH, Yang HS, Park YD, Yang JM. Analysis of the peptides detected in atopic dermatitis and various inflammatory diseases patients-derived sera. Int J Biol Macromol. 2018 Jan;106:1052-1061.
  2. Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park, Jun-Mo Yang. Serum proteomic analyses for probing C3 fragment protein. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 981-988.
  3. Shang-Jun Yin, Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park, Jun-Mo Yang. An integrated method for the detection of basic proteins in serum-derived proteomes. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 973-980.
  4. Shang-Jun Yin, Daeui Park, Yue-Xiu Si, Hae Young Chung, Yong-Doo Park, Jun-Mo Yang. An RNA interference based study for the role of ALDH1 in keratinocytes: DNA microarray, antibody–chip array and bioinformatics approaches. Process Biochemistry, Volume 49, Issue 10, October 2014, Pages 1612-1621.
  5. Yin SJ, Si YX, Zhang M, Qian GY, Zhang F, Yan L, Lü ZR, Zhou HM, Yang HS, Park YD, Yang JM. Combination of free-flow electrophoresis and interactomics to analyze the dysregulated proteins of fibroblasts from atopic dermatitis patients. J Dermatol Sci. 2011 Feb;61(2):148-50.
  6. Park YD*, Park D, Bhak J, Yang JM. Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics. Proteomics Clin Appl. 2008 Mar;2(3):290-300.
  7. Park YD, Lyou YJ, Yang JM. Two-dimensional electrophoresis analyses of atopic dermatitis and the chances to detect new candidate proteins by the variations in immobilized pH gradient strips. J Dermatol Sci. 2007 Jul;47(1):9-17.
  8. Park YD, Lyou YJ, Yang JM. Detection of down-regulated acetaldehyde dehydrogenase 1 in atopic dermatitis patients by two-dimensional electrophoresis. Exp Dermatol. 2007 Feb;16(2):130-4.
  9. Park YD, Lyou YJ, Lee KJ, Lee DY, Yang JM. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Clin Exp Allergy. 2006 May;36(5):649-57.
  10. Park YD, Jang HS, Kim SY, Ko SK, Lyou YJ, Lee DY, Paik YK, Yang JM. Two-dimensional electrophoretic profiling of atopic dermatitis in primary cultured keratinocytes from patients. Proteomics. 2006 Feb;6(4):1362-70.
  11. Park YD, Kim SY, Jang HS, Seo EY, Namkung JH, Park HS, Cho SY, Paik YK, Yang JM. Towards a proteomic analysis of atopic dermatitis: a two-dimensional-polyacrylamide gel electrophoresis/mass spectrometric analysis of cultured patient-derived fibroblasts. Proteomics. 2004 Nov;4(11):3446-55.

Pigmentation research (皮膚黑色素研究):

  1. Proteomic analyses for profiling regulated proteins/enzymes by Fucus vesiculosus fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study.
  2. Wang ZJ, Zheng L, Yang JM, Kang Y, Park YD*. Int J Biol Macromol. 2018 Jun;112:667-674.
  3. Shang-Jun Yin, Kun-Yuan Liu, Jinhyuk Lee, Jun-Mo Yang, Guo-Ying Qian, Yue-Xiu Si, Yong-Doo Park*. Effect of hydroxysafflor yellow A on tyrosinase: Integration of inhibition kinetics with computational simulation. Process Biochemistry, Volume 50, Issue 12, December 2015, Pages 2112-2120.
  4. Wei Wang, Daeui Park, Sunyoung Ji, Shang-Jun Yin, Guo-Ying Qian, Hae Young Chung, Jun-Mo Yang, Jinhyuk Lee, Yong-Doo Park*. Computational prediction for the protein interactions of tyrosinase: Protein experimental interactome MAP. Process Biochemistry, Volume 48, Issue 4, April 2013, Pages 638-648.
  5. Si YX, Wang ZJ, Park D, Chung HY, Wang SF, Yan L, Yang JM, Qian GY, Yin SJ, Park YD*. Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study. Int J Biol Macromol. 2012 Jan 1;50(1):257-62.
  6. Yin SJ, Si YX, Wang ZJ, Wang SF, Oh S, Lee S, Sim SM, Yang JM, Qian GY, Lee J, Park YD*. The effect of thiobarbituric acid on tyrosinase: inhibition kinetics and computational simulation. J Biomol Struct Dyn. 2011 Dec;29(3):463-70.
  7. Lü ZR, Seo E, Yan L, Yin SJ, Si YX, Qian GY, Park YD*, Yang JM. High-throughput integrated analyses for the tyrosinase-induced melanogenesis: microarray, proteomics and interactomics studies. J Biomol Struct Dyn. 2010 Oct;28(2):259-76.

部分授權專利、軟件著作權及其他

  1. 特應性皮炎角質細胞或血清衍生的生物標志物(10-1109043)發明人:Yang Jun Mo(梁俊莫),Park Yong Doo(樸龍斗)
  2. 外源性特應性皮炎的生物標志物(10-1105811)發明人:Yang Jun Mo(梁俊莫),Park Yong Doo(樸龍斗)
  3. 普遍特應性皮炎的生物標志物(10-1117799)發明人:Yang Jun Mo(梁俊莫),Park Yong Doo(樸龍斗)
  4. 色素過多的生物標志物及其應用(10-1109739)發明人:Yang Jun Mo(梁俊莫),Park Yong Doo(樸龍斗)
  5. 三氟乙醇用于酪氨酸酶活性調控(10-1123149)發明人:Yang Jun Mo(梁俊莫),Park Yong Doo(樸龍斗)

其他

作為Lead Guest Editor在《Enzyme Research》雜志上出版了Special Issue: Skin diseases-related enzymes: mechanisms and clinical applications.

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